DNA Platinum

The discovery of the antitumorais properties of the cisplatina constitutes a landmark in the history of Chemistry Medicinal, which, initially, mainly dedicated to the organic study of composition and natural products. After this discovery it can be said that a new perspective confided, with the inclusion of metallic complexes as possible therapeutical agents (Mire et al., 2002). Since then some works if had dedicated to investigate the mechanism of action of the cisplatina and composites correlatos in the organism. These studies had shown that, before reaching the cells, the complexes pass for substitution reactions, being the most important hydrolysis reaction. One of to be answered the now questions was: after to suffer hydrolysis in the intracellular way, which would be the biological target of the complex, since many cellular components, as the DNA, the RNA and the proteins can interact with platinum? (War et al., 2005). The antineoplsicos formed for made up of coordination with platinum, as the cisplatina and the carboplatina, alquilam the DNA. The action mechanism is related with the inhibition selective of the synthesis of the DNA.

The cytotoxic properties of these composites, as well as of numerous analogous, have been attributed its ability to form crossed linkings of the type as well as interfilamentares intrafilamentares. More recently, particular emphasis to the capacity of the cisplatina in provoking mutations in the DNA has been given and modifying the linking DNA-protein. The platinum complexes seem to have synergic effect with other antitumorais agents (Sources et al., 2005). The cisplatina, although to have been described it has 150 years more than, in last the 30 years only is that she has been recognized as a powerful antitumoral agent. The main small farm of linking is nitrogen 7 of the guanina (N-7), even so also covalente with adenosine and the citosina occurs interaction. It is standed out that the cisplatina exerts accented antitumoral activity in the genitourinrios cancers, particularly testicular, the ovariano and the vesical.

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